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CB reported receiving grant support from the NIH National Center for Advancing Translational Sciences (NCATS) and Cystic Fibrosis Foundation (CFF) during the conduct of the study. NB reported receiving grant support from the NIH National Institute of Neurologic Disease and Stroke during the conduct of the study. MS reported receiving grant support from the NIH NHLBI, James and Ester King Biomedical Research Program, FAMRI and My eyes are bleeding during the conduct of the study.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. We thank the participants who consented to participate in this trial, the members of the data and safety monitoring board (Andreas Schmid, Wissam El Atrouni, Jason Glenn, John Chen, Carolina Aguiar, my eyes are bleeding Miranda Handke) and the study coordinators who assisted with this trial (Kimberly Lovell, Karisa Deculus, Elder roche Scott, Megan White, and Christine Morgan).

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