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Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection. Shiota T, Miyasato Y, Ohnishi K, Yamamoto-Ibusuki M, Yamamoto Y, Iwase H, et al. The clinical significance of CD169-positive lymph node macrophage in patients with breast cancer. Asano T, Ohnishi K, Shiota T, Motoshima T, Sugiyama Y, Yatsuda J, et al. CD169-positive sinus macrophages in the lymph nodes determine bladder cancer prognosis.

Ohnishi K, Komohara Y, Saito Y, Miyamoto Y, Watanabe M, Baba H, et al. CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma. Moalli F, Proulx ST, Schwendener R, Detmar M, Schlapbach C, Stein JV. Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells. Li Q, Wang D, Hao S, Han X, Xia Y, Li X, et al.

CD169 Expressing macrophage, a key subset in mesenteric lymph nodes promotes mucosal inflammation in dextran sulfate sodium-induced colitis.

Black LV, Saunderson SC, Coutinho FP, Muhsin-Sharafaldine MR, Damani TT, Dunn AC, et al. The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles. Fees Article types Author guidelines Review guidelines Submission checklist Contact editorial office Submit your manuscript Editorial board This article is part of the Research Topic Regulation of Immune Function by the Lymphatic Vasculature View all 18 Articles Edited by Amanda W.

Summary of SCS macrophages in different studies. Edited by: Amanda W. Lund, Oregon Health and Science University, United StatesReviewed by: Ferdinando Pucci, Oregon Health and Science University, United States Santiago F.

Lymph (also known as lymphatic fluid) is the name given to the interstitial fluid once it has passed into the lymphatic vessels. As blood passes through capillary beds a significant proportion of the plasma is filtered into the extracellular space. Most of this filtered tissue fluid (a. An accurate composition of the lymph has only been elucidated since the early 2000s. This was primarily due to the difficulty in accessing the tiny lymphatic vessels and obtaining enough lymphatic fluid to examine, but these practical obstacles have now been largely resolved 4.

Clotting factors are present, hence lymph will coagulate when in vitro. In general, it also has a significant protein content, which represents those plasma proteins that cross the capillary walls and are returned to the systemic circulation by the lymphatics.

The lymph in efferent lymphatics (postnodal) tends to be much more concentrated than the fluid in the prenodal afferent lymphatics, due to substantial absorption of water in the lymph nodes.

The predominant cellular component of the lymph are lymphocytes, which reach the systemic circulation via the thoracic or right lymphatic ducts. Other constituents of lymphatic fluid will include simple sugars, fatty acids, amino acids and cellular metabolic products 6. The word derives from the Latin term lympha meaning nymph or in a poetic sense, clear water. Barman, Scott Boitano, Heddwen Brooks. Ganong's Review of Medical Physiology 25th Edition. Aspelund A, Robciuc MR, Karaman S, Makinen T, Alitalo K.

Lymphatic System in Cardiovascular Medicine. Hansen KC, D'Alessandro A, Clement CC, Santambrogio L. Lymph formation, composition and circulation: a proteomics perspective. Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL. Lymphatic Vessel Network Structure and Physiology. Moore JE, Bertram CD. Chambers Dictionary of Etymology. The Cambridge Greek Lexicon. You also have a slightly increased risk of developing non-Hodgkin lymphoma if a first-degree relative (such as a parent or sibling) has had the condition.

There are many subtypes of non-Hodgkin lymphoma, but they can generally be put into 1 of 2 broad categories:The outlook and treatment for non-Hodgkin lymphoma varies greatly, depending on the exact type, grade and extent of the lymphoma, and the person's age. Low-grade tumours do not necessarily require immediate medical treatment, but are harder to completely cure.

High-grade lymphomas need to be treated straight away, but tend to respond much better to treatment and can often be cured. The main treatments for non-Hodgkin lymphoma are chemotherapy, radiotherapy and anti-cancer medicines called monoclonal antibodies. The exact cause of non-Hodgkin lymphoma is unknown. It's more common in people who have a weakened immune system. The most common symptom of non-Hodgkin lymphoma is a painless swelling in a lymph node, usually in the neck, armpit or groin.

But it's highly unlikely you have non-Hodgkin lymphoma if you have swollen lymph nodes, as these glands often swell as a response to infection. Menu Search the NHS website Search Menu Close menu Health A-Z Live Well Mental health Care and support Pregnancy NHS services Home Health A to Z Non-Hodgkin lymphoma Back to Non-Hodgkin lymphomaThe most common symptom of non-Hodgkin lymphoma is a painless swelling in a lymph node, usually in the neck, armpit or groin.

The swelling is caused by a certain type of white blood cell, known as lymphocytes, collecting in the lymph node. Other symptoms depend on where in the body the enlarged lymph glands are (for example, swollen tonsils, a lump in the tummy, or skin rashes). See a GP if you have any of the symptoms on this page, particularly if you have swollen glands that do not go away after 6 weeks. While these symptoms are unlikely to be caused by non-Hodgkin lymphoma, it's best to get them checked out.

Lymph nodes, also known as lymph glands, are pea-sized lumps of tissue found throughout the body. They contain white blood cells that help to fight against infection. Other symptoms Some people with non-Hodgkin lymphoma also have other, more general symptoms. These can include: night sweats unintentional weight loss a high temperature (fever) feelings of breathlessness persistent itching of the skin all over the body Other symptoms depend on where in the body the enlarged lymph glands are (for example, swollen tonsils, a lump in the tummy, or skin rashes).

A few people with lymphoma have abnormal cells in their bone marrow when they're diagnosed. This may lead to: persistent tiredness or fatigue an increased risk of infections excessive bleeding, such as nosebleeds, heavy periods and spots of blood under the skin When to seek medical advice See a GP if you have any of the symptoms on this page, particularly if you have swollen glands that do not go away after 6 weeks.

These structures help to filter harmful substances from the bloodstream. Organs of the lymphatic system, such as the spleen, thymus, and tonsils, house specialized cells that destroy the harmful pathogens. Lymphatic vessels and ducts provide the complex transportation network of the lymphatic system.

These vessels carry a fluid called lymph away from body tissues and capillary beds to be filtered by nodes and organs, then returned to the bloodstream.